Publications by authors named "C B Post"
Purpose: The presence of MYC and BCL2 translocations (ie, double-hit lymphoma, DHL) in large B-cell lymphoma (LBCL) is associated with reduced chemosensitivity, but less is known on its impact on radiotherapy (RT) efficacy.
Methods And Materials: Patients with LBCL who received their first course of RT for relapsed/refractory disease between 2008 and 2020 were eligible if there was adequate pathologic evaluation to be categorized as DHL versus non-DHL as per the World Health Organization (fifth edition). Separate analyses were conducted by treatment intent.
Objectives: Approximately 15% of patients with localized prostate cancer are at high risk for disease recurrence. Many clinical trials have evaluated the impact of neoadjuvant therapy before radical prostatectomy with mixed results (NCT00321698).
Methods: This phase I/II clinical trial evaluated the tolerability and preliminary efficacy of neoadjuvant radiation therapy and docetaxel before prostatectomy in 25 men with high-risk prostate cancer.
Article Synopsis
- Recent research on the HER2-targeted therapy trastuzumab-deruxtecan has led to a study examining HER2-low status in over 800 advanced endometrial cancer (EC) cases, which typically have a poor prognosis despite numerous treatment options.
- The study found that 17.2% of tumors were HER2-low, with higher frequencies in recurrent or metastatic EC (35.6%) and primary stage IV EC (29.9%), indicating HER2 status is present across various EC classifications without independent prognostic value.
- The findings suggest that a significant portion of high-risk and metastatic EC cases exhibit HER2 overexpression, emphasizing the importance of broad HER2 testing and potential treatment opportunities for diverse patient groups.
The recruitment of the protein spleen tyrosine kinase (Syk) to membrane-bound immune receptors is an essential step in initiating an immune response mediated through the activated receptors. Syk recognizes intracellular phosphorylated regions of membrane receptors known as immunoreceptor tyrosine-based activation motifs (ITAMs) defined by a sequence with two tyrosine (Y) amino acids separated by a certain spacing of six to eight residues: YXX(I/L)XYXX(I/L). Syk with doubly phosphorylated ITAM is high-affinity and negatively regulated when Syk itself becomes phosphorylated.
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