Insight into the molecular initiating event of mutagenic N-nitrosamines: a computational study on DNA alkylation by their diazonium ions.

N-Nitrosamines are a class of compounds that includes the potent mutagenicity and carcinogenicity of many of its members and is distributed widely throughout the human environment. DNA alkylation by their diazonium ions formed metabolically acts as a molecular initiating event (MIE) that links molecular chemistry to mutagenicity. However, the regiochemistry for diazonium ions reacting with DNA bases is still under debate.

The impact of the interaction between BDNF rs7103411 gene polymorphism and social activities on mild cognitive impairment in community-dwelling elderly adults.

Objective: To investigate the correlation between BDNF gene polymorphism, BDNF levels, and susceptibility to mild cognitive impairment (MCI).

Methods: In this study, we investigated 107 elderly adults individuals from a community in Zhongshan, Guangdong Province, with an average age of 73.17 ± 7.

Association between ambient temperature and couple fecundity: Insights from a large-scale cohort study in Yunnan, China.

Background: Direct evidence linking ambient temperature to human fecundity is sparse. We aimed to evaluate the potential impact of ambient temperature on time to pregnancy (TTP) and identify the optimal temperature range for initiating conception attempts.

Methods: Our analysis included 576 927 couples from the Chinese National Free Preconception Health Examination Project (NFPHEP) in Yunnan Province, with a one-year follow-up post-enrollment.

Tunable optical nonreciprocity in double-cavity optomechanical system with nonreciprocal coupling.

We propose a double-cavity optomechanical system with nonreciprocal coupling to realize tunable optical nonreciprocity that has the prospect of making an optical device for the manipulation of information processing and communication. Here we investigate the steady-state dynamic processes of the double-cavity system and the transmission of optical waves from opposite cavity directions. The transmission spectrum of the probe field is presented in detail and the physical mechanism of the induced transparency window is analyzed.

Association of Pretreatment Serum Indirect Bilirubin Levels With Prognostic and Therapeutic Value in Patients With Newly Diagnosed Acute Myeloid Leukemia.

Background: Bilirubin has anti-inflammatory, antioxidant, and anti-cancer properties, with an inverse relationship between its levels and cancer risk and prognosis. However, the prognostic value of serum bilirubin in acute myeloid leukemia (AML) remains uncertain.

Methods: This retrospective study analyzed pretreatment serum total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL) in 284 AML patients and 316 healthy controls.