Publications by authors named "C B Granja"
Purpose: With the increasing use of proton therapy, there is a growing emphasis on including radiation quality, often quantified by linear energy transfer, as a treatment plan optimization factor. The Timepix detectors offer energy-sensitive particle tracking useful for the characterization of proton linear energy transfer. To improve the detector's performance in mixed radiation fields produced in proton therapy, we customized the detector settings and performed the per-pixel energy calibration.
View Article and Find Full Text PDFOrthotopic tumor models in pre-clinical translational research are becoming increasingly popular, raising the demands on accurate tumor localization prior to irradiation. This task remains challenging both in x-ray and proton computed tomography (xCT and pCT, respectively), due to the limited contrast of tumor tissue compared to the surrounding tissue. We investigate the feasibility of gadolinium oxide nanoparticles as a multimodal contrast enhancement agent for both imaging modalities.
View Article and Find Full Text PDFArticle Synopsis
- Patients with chronic critical illness (CCI) often experience acquired muscle weakness, making optimal protein intake crucial for their recovery, but guidelines on the ideal protein levels remain unclear.
- A systematic review was conducted by searching major databases for studies comparing high versus low protein intake in critically ill adults who had been in the ICU for more than a week.
- The analysis included four studies with over 1,700 patients, revealing that higher protein intake (greater than 1.3g/kg/day) significantly reduced early mortality rates in these patients.
Article Synopsis
- This study examines how cardiovascular responses (like heart rate and blood pressure) can help predict the outcomes for children with acute acquired brain injury (ABI) who are admitted to the pediatric intensive care unit (PICU).
- The research included 72 children, where significant associations were found between conditions like tachycardia and abnormal blood pressure levels and their likelihood of mortality.
- The findings suggest that the Poincaré SD1/SD2 ratio may be a useful tool for predicting mortality in these patients, indicating the need for larger studies to confirm these results.
Background: Cross-organizational access to shared electronic health records can enhance integrated, people-centered health services. However, a gap remains between these potential benefits and the limited support currently offered by electronic health records. The Valkyrie research project aims to bridge this gap by developing a technical prototype of an architecture to promote healthcare service coordination.
View Article and Find Full Text PDF