Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature.

Acute myeloid leukemia (AML) with the high-risk variant inv(3)/t(3;3) or t(3;3)(q21;26.2) is rarely seen in the pediatric and young adult population. It is associated with poor outcomes with ineffective therapeutic options.

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.

The melanocortin-4 receptor (MC4R) is a centrally expressed, class A GPCR that plays a key role in the regulation of appetite and food intake. Deficiencies in MC4R signaling result in hyperphagia and increased body mass in humans. Antagonism of MC4R signaling has the potential to mitigate decreased appetite and body weight loss in the setting of anorexia or cachexia due to underlying disease.

Intersecting distributed networks support convergent linguistic functioning across different languages in bilinguals.

How bilingual brains accomplish the processing of more than one language has been widely investigated by neuroimaging studies. The assimilation-accommodation hypothesis holds that both the same brain neural networks supporting the native language and additional new neural networks are utilized to implement second language processing. However, whether and how this hypothesis applies at the finer-grained levels of both brain anatomical organization and linguistic functions remains unknown.

Dipole moment background measurement and suppression for levitated charge sensors.

Optically levitated macroscopic objects are a powerful tool in the field of force sensing, owing to high sensitivity, absolute force calibration, environmental isolation, and the advanced degree of control over their dynamics that have been achieved. However, limitations arise from the spurious forces caused by electrical polarization effects that, even for nominally neutral objects, affect the force sensing because of the interaction of dipole moments with gradients of external electric fields. Here, we introduce a technique to measure, model, and eliminate dipole moment interactions, limiting the performance of sensors using levitated objects.

The impact of contact tracing and testing on controlling COVID-19 outbreak without lockdown in Hong Kong: An observational study.

Background: Maintaining effective contact tracing to control COVID-19 is challenging. Rapid growth in the number of infected cases can overload tracing and testing capacity, resulting in failure to trace contacts and delays in confirming an infection until after symptom onset (confirmation delay), hence increasing transmissibility. A substantial outbreak in Hong Kong, which was suppressed with non-pharmaceutical interventions (NPIs), provided an opportunity to assess the impact of overloading contact tracing and of efforts to improve its efficiency.