Publications by authors named "C B Belli"
Background: Early-phase clinical trials offer a unique opportunity for patients with cancer. These trials often mandate biopsies to collect tumor tissue for research purposes, requiring patients to undergo invasive procedures. Some trials mandate molecular prescreening, but the success of these analyses relies on the quality and quantity of the tested materials.
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- The immune system in chronic myeloid leukemia (CML) patients is significantly weakened, affecting their ability to respond to tumors, but shows improvement following effective treatment with tyrosine kinase inhibitors like imatinib.
- A study analyzed gene expression of various immune mediators in 171 blood samples from CML patients over their first year on imatinib, comparing it with samples from healthy donors.
- Results indicated that most immune mediators initially declined but largely normalized over time, while also revealing different patterns in optimal versus non-optimal treatment responders.
Molecular tumor board in patients with metastatic breast cancer.
Breast Cancer Res Treat
October 2024
Purpose: Comprehensive genomic profiling is becoming increasingly important in the management of patients with metastatic breast cancer (mBC). Real-world clinical outcomes from applying molecular tumor boards (MTBs) recommendations in this context remain limited. Accordingly, we conducted a retrospective, single-institution analysis to evaluate the clinical impact of discussing patients affected by mBC at the MTB.
View Article and Find Full Text PDFBackground: Somatic genetic alterations of the estrogen receptor 1 gene (ESR1) are enriched in endocrine therapy-resistant, estrogen receptor-positive (ER+) metastatic breast cancer (mBC). Herein, we investigated and compared the clinical and genomic landscape of ESR1-mutant (ESR1) and ESR1 wild type (ESR1) ER+/ human epidermal growth factor receptor 2 (HER2)- mBCs.
Methods: Clinical and genomic data were retrieved from cBioPortal using the publicly-available MSK MetTropism dataset.
Article Synopsis
- Exercise intensity in horses is self-regulated, influenced by factors like social behaviors and operant conditioning, and may increase when another horse is seen ahead.
- In an experiment with seven horses, displaying a video of a trotting horse led to higher heart rates, plasma lactate levels, and specific behavioral changes compared to a control image without horses.
- The findings suggest that visual stimuli can motivate horses to exercise more intensely, indicating the ability of horses to adapt to social cues without the need for harsh training methods like using a whip.