Publications by authors named "C Azoulay"

Objective: Pollution is one of the world's largest risk factors for disease and premature death. In Europe, it is responsible for approximately 20% of mortality. Chemicals exposure can occur by inhalation, ingestion or skin contact and begins in utero.

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EBV-positive inflammatory follicular dendritic cell sarcoma (EBV+ inflammatory FDCS) is a rare neoplasm almost exclusively located in the spleen or liver. It is characterized by a proliferation of EBV-positive spindle-shaped cells bearing follicular dendritic cell markers, associated with an abundant lymphoplasmacytic infiltrate. EBV+ inflammatory FDCS is often asymptomatic or responsible for mild symptoms.

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Article Synopsis
  • - The study investigated the relationship between thrombotic events in severe COVID-19 cases and hemostasis dysregulation, aiming to identify soluble markers and gene-expression patterns that reflect disease severity and patient outcomes.
  • - Results showed that elevated levels of soluble P-selectin (sP-selectin) at patient admission correlated with higher severity, predicting the need for intubation and risk of death, with specific cutoff values indicating their predictive power.
  • - The findings suggest that platelet activation plays a significant role in the severity of COVID-19, with certain biomarkers like PPBP/CXCL7 and SELPLG identified for predicting intubation; further studies are needed to validate these markers.
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We report the case of an HIV-1-infected patient, treated with anti-CD20 monoclonal antibody for a B-cell lymphoma previously treated by autologous stem cell transplant. He suffered from chronic COVID19 and we monitored by plasma SARS-CoV-2 RNA by highly sensitive droplet-based digital PCR technology (ddPCR). Under tocilizumab therapy and despite a first clinical improvement biologically associated with decreasing inflammatory markers, a slight increase of SARS-CoV-2 RNAaemia quantified by ddPCR was highlighted, confirming the absence of viral efficacy of this treatment and predicting the subsequent observed deterioration.

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