Publications by authors named "C Autumn Vetter"
Background And Purpose: Myeloid-derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP receptor agonist L-902,688 and pegylated human Arginase-1 on MDSCs in a murine model of chronic asthma and asthma exacerbation.
View Article and Find Full Text PDFAdolescents and young adults (AYAs), often defined as those aged 15-39 years, face unique challenges in oncology that are often unmet by conventional care models. This systematic review examines evidence on establishing dedicated AYA oncology units, focusing on logistical, infrastructural, and personnel-related recommendations. A PRISMA-guided search of PubMed (2000-2024) identified seven studies that emphasized early stakeholder involvement and collaboration between pediatric and adult oncology teams to ensure comprehensive care.
View Article and Find Full Text PDFObjective: The purpose of this study was to describe clinical complications and healthcare resource utilization (HCRU) among patients with sickle cell disease (SCD) with recurrent vaso-occlusive crises (VOCs) and patients with transfusion-dependent β-thalassemia (TDT) in Germany.
Methods: The Betriebskrankenkasse (BKKs) Database was used to identify patients with SCD or TDT. To be eligible for inclusion, patients with SCD were required to have ≥ 2 VOCs/year in any two consecutive years and ≥ 12 months of available data before and after the index date (second VOC in the second consecutive year).
Negative Association Between Schizophrenia and Subsequent Cancer Diagnoses-A Retrospective Cohort Study from Germany.
Eur J Investig Health Psychol Educ
November 2024
Background: Since previous studies have reported contradictory findings regarding the relationship between schizophrenia and cancer, we evaluated the association between schizophrenia and cancer diagnoses.
Methods: In this retrospective cohort study, the IQVIA Disease Analyzer database was utilized to examine the incidence of cancer among patients aged over 18 years diagnosed with schizophrenia in German general practices from 2005 to 2022. Patients with schizophrenia were compared with those without the condition, with adjustments made for age, sex, index year of diagnosis, average annual practitioners visit frequency, and comorbidity.
Article Synopsis
- Traumatic brain injury (TBI) may be linked to an increased risk of Alzheimer's disease (AD), potentially due to its influence on the onset of cognitive symptoms and pathological protein deposition, although the exact mechanisms remain unclear.
- A review of studies utilizing PET imaging to measure β-amyloid and tau in individuals with a history of TBI highlighted common methodological issues and found inconsistent results, particularly concerning sample size and reliance on self-reported TBI.
- The most compelling evidence for increased β-amyloid was found in the cingulate gyrus and cuneus/precuneus, while tau showed elevated levels in various brain regions, though conflicting results underscore the need for further research with larger, more detailed studies.