Publications by authors named "C Arundel"
Background: Dupuytren's contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing limited fasciectomy with collagenase injection.
View Article and Find Full Text PDFBackground: National heart failure guidelines recommend quadruple therapy with renin-angiotensin system inhibitors, beta-blockers, mineralocorticoid receptor antagonists, and sodium-glucose cotransporter 2 inhibitors for patients with heart failure with reduced ejection fraction (HFrEF), most of whom also receive loop diuretics. However, the guidelines are less clear about the safe approaches to discontinuing older drugs whose decreasing or residual benefit is less well understood. The objective of this study was to examine whether digoxin can be safely discontinued in patients with HFrEF receiving beta-blockers.
View Article and Find Full Text PDFArticle Synopsis
- - The study compares the effectiveness of two treatments for Dupuytren's contracture: collagenase injection and limited fasciectomy, using a randomized controlled trial with 672 participants
- - The main measurement tool used was the Patient Evaluation Measure-Hand Health Profile (PEM), where scores range from 0 to 100, with higher scores indicating worse hand health; results showed a mean score of 17.8 for the collagenase group and 11.9 for the limited-fasciectomy group at 1 year
- - The findings concluded that collagenase injection was not as effective as limited fasciectomy after one year, with fewer complications reported in the collagenase group (1.8%) compared to the limited-fasc
Article Synopsis
- A study investigated the potential benefits of methotrexate, an antirheumatic drug, in treating knee osteoarthritis (KOA) pain through a multicenter, double-blind, placebo-controlled trial involving 207 participants.
- Participants were randomly assigned to receive either methotrexate or a placebo for 12 months while continuing their usual pain relief medications, with a primary focus on assessing average knee pain at 6 months.
- Results indicated that the methotrexate group experienced a significant decrease in knee pain compared to the placebo group, suggesting methotrexate may provide symptomatic relief for KOA.
Background: Alcohol withdrawal is a common reason for admission to acute care hospitals. Prescription of medications for alcohol-use disorder (AUD) and close outpatient follow-up are commonly recommended, but few studies report their effects on postdischarge outcomes.
Objectives: The objective of this study is to evaluate the effects of medications for AUD and follow-up appointments on readmission and abstinence.