Publications by authors named "C Aravanis"
Toll-like receptors (TLRs) are the key regulators of innate and adaptive immunity and are highly expressed during sepsis. Thus, studying the expression of TLRs in an animal septic model might indicate their possible association with acute kidney injury in sepsis. Seventy-two male C57BL/6J mice were used for this study.
View Article and Find Full Text PDF: To investigate the expression of toll-like receptors (TLRs) in the liver of septic mouse model. : For this study seventy-two C57BL/6J mice were utilized. Sepsis was induced by cecal ligation and puncture (CLP) in the mice of the three septic (S) groups (euthanized at 24 hours, 48 hours and 72 hours).
View Article and Find Full Text PDFArticle Synopsis
- Sepsis significantly affects blood cell counts, showing decreased white blood cells (WBCs) and lymphocytes across all sepsis groups compared to controls.
- The levels of certain biochemical markers, such as creatinine and interleukins (IL-10 and IL-6), were notably elevated in the sepsis groups, indicating an inflammatory response.
- Toll-like receptors (TLRs) 2, 3, 4, and 7 showed increased expression in the lungs of sepsis models, suggesting their role in respiratory system involvement during sepsis and serving as a potential severity indicator.
Overexpression of Toll-Like Receptors 2, 3, 4, and 8 Is Correlated to the Vascular Atherosclerotic Process in the Hyperlipidemic Rabbit Model: The Effect of Statin Treatment.
J Vasc Res
June 2017
Background: Atherosclerosis is the major cause of cardiovascular disease; hypercholesterolemia is a major risk factor. We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response. We determined the association of atherosclerotic lesions and TLR mRNA expression in different aortic sites.
View Article and Find Full Text PDFBackground: In 1960, all male inhabitants of a series of villages in rural Crete, born between 1900 and 1919, were invited to participate in the Seven Countries Study. Analysis of 25-year mortality data from the 16 cohorts of participants indicated that the cohort from Crete had the lowest age-standardised all-cause and coronary heart disease death rates.
Methods: At baseline, 686 Cretan men (98% of those invited) participated in health examinations.