Publications by authors named "C Arama"
Article Synopsis
- Pregnancy may lead to increased neutrophil levels, which are crucial for fighting infections, particularly in severe neutropenia cases.
- A study in Mali found that nearly half of the pregnant women exhibited neutrophilia, while most cases of neutropenia were among healthy, non-pregnant individuals.
- Neutrophil levels were significantly lower in the first trimester compared to later stages, and this increase was not influenced by malaria infections.
Introduction: Polymorphonuclear neutrophils (PMN) are involved in pathogen clearance by phagocytosis. However, the role of PMNs in the efficacy of artemisinin-based combination therapy (ACT) is poorly understood.
Methodology: In a prospective longitudinal in vivo study, neutrophil rates were compared with malaria carriage after treatment with different ACTs: Artemether - lumefantrine (AL), Artesunate - amodiaquine (ASAQ), Dihydroartemisinin - piperaquine (DP) or Pyronaridine artesunate (PA).
Host immunity has been suggested to clear drug-resistant parasites in malaria-endemic settings. However, the immunogenetic mechanisms involved in parasite clearance are poorly understood. Characterizing the host's immunity and genes involved in controlling the parasitic infection can inform the development of blood-stage malaria vaccines.
View Article and Find Full Text PDFBackground: (Pf) Sporozoite (SPZ) Chemoprophylaxis Vaccine (PfSPZ-CVac) involves concurrently administering infectious PfSPZ and malaria drug, often chloroquine (CQ), to kill liver-emerging parasites. PfSPZ-CVac (CQ) protected 100% of malaria-naïve participants against controlled human malaria infection. We investigated the hypothesis that PfSPZ-CVac (CQ) is safe and efficacious against seasonal, endemic Pf in malaria-exposed adults.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how cumulative malaria exposure affects dendritic cells in adults from Mali, particularly looking at those who are uninfected versus asymptomatically infected with Plasmodium falciparum, the malaria-causing parasite.
- Researchers found that while uninfected adults' dendritic cells responded well to malaria parasite stimulation, those with asymptomatic infections did not show significant immune responses, suggesting potential impairment in their immune function.
- Elevated levels of certain cytokines (IL-10 and CXCL9) were observed in both asymptomatic adults and children with acute malaria, indicating ongoing immune activity despite the lack of symptoms in some individuals.