Benchmarking strategic alignment of business and IT strategies: opportunities, risks, challenges and solutions.

Business and IT strategy alignment is a complex dynamic process in which organizations are in a position to enable extensive IT capabilities to achieve their business objectives. This interdependence is amplified by the COVID-19 crisis, which makes the integration of IT and business strategies more important than ever. This paper mainly aims to contribute to the understanding of strategic alignment from a practical perspective, as well as to demonstrate the applicability and robustness of the Strategic Alignment Model (SAM).

Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma. The Hellenic experience.

This retrospective study aimed to describe the Hellenic experience on the use of brentuximab vedotin (BV) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) given within its indication. From June 2011 to April 2015, ninety-five patients with R/R HL, who received BV in 20 centers from Greece, were analyzed. Their median age was 33 years, and 62% were males.

Unique localization of circulating tumor cells in patients with hepatic metastases.

Purpose: There are few data on the impact of immediate and differing surgical interventions on circulating tumor cells (CTCs), nor their compartmentalization or localization in different anatomic vascular sites.

Patients And Methods: CTCs from consecutive patients with colorectal liver metastases were quantified before and immediately after open surgery, laparoscopic resection, open radiofrequency ablation (RFA), or percutaneous RFA. For individuals undergoing open surgery, either hepatic resections or open RFA, CTCs were examined in both systemic and portal circulation by measuring CTCs in samples derived from the peripheral vein, an artery, the hepatic portal vein, and the hepatic vein.

Prediction of local cellular deformation in bone--influence of microstructure dimensions.

A multilevel finite element approach is applied to predict local cell deformations in bone tissue. The loads applied to a whole femur during the stance phase of the gait cycle were related to the strain at the level of a single lacuna and of canaliculi. Cell deformations were predicted from detailed linear FE analysis of the microstructure, consisting of an arrangement of cells embedded in bone matrix material.

Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients.

Aims: Studies of EGFR expression in breast cancer have shown inconsistent results due in part to a large range of methods used. Anti-EGFR therapy trials have often not used patient selection because of this. We describe the use of the CellSearch system (Veridex LLC, NJ, USA) to enumerate and measure EGFR expression on the surface of circulating tumor cells (CTCs), derived from the peripheral blood of individuals with metastatic breast cancer over time.