Publications by authors named "C Anceschi"
Cellular senescence is a permanent cell growth arrest that occurs in response to various intrinsic and extrinsic stimuli and is associated with cellular and molecular changes. Long non-coding RNAs (lncRNAs) are key regulators of cellular senescence by affecting the expression of many important genes involved in senescence-associated pathways and processes. Here, we evaluated a panel of lncRNAs associated with senescence for their differential expression between young and senescent human dermal fibroblasts (NHDFs) and studied the effect of a known senomorphic compound, resveratrol, on the expression of lncRNAs in senescent NHDFs.
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- Research Focus
- : The study investigates how fatty acid metabolism impacts stem-like characteristics in intrahepatic cholangiocarcinoma (iCCA), a serious type of liver cancer.
- Key Findings
- : Cancer cells with stem-like features (SPH) have higher levels of free fatty acids and lipid synthesis enzymes compared to regular cells. Inhibition of fatty acid synthase (FASN) reduces these stem characteristics and tumor growth in lab models.
- Clinical Implications
- : Targeting fatty acid metabolism could provide new strategies for treating iCCA, potentially improving patient survival and slowing disease progression.
Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process.
Pharmaceuticals (Basel)
April 2024
Article Synopsis
- The study investigates the roles of two enzymes, IDO1 and TDO, in breaking down tryptophan into kynurenine, focusing on their impact on angiogenesis in human endothelial cells.* -
- Using various methods like qRT-PCR and ELISA assays, the research shows that TDO is crucial for the proliferation and tube formation of HUVECs in response to VEGF-A, while IDO1 did not have a significant effect.* -
- The findings suggest that TDO plays a significant role in endothelial cell function and could be important in angiogenesis, indicating a broader role than just immune regulation.*
Hyponatremia is the prevalent electrolyte imbalance in cancer patients, and it is associated with a worse outcome. Notably, emerging clinical evidence suggests that hyponatremia adversely influences the response to anticancer treatments. Therefore, this study aims to investigate how reduced extracellular [Na] affects the responsiveness of different cancer cell lines (from human colon adenocarcinoma, neuroblastoma, and small cell lung cancer) to cisplatin and the underlying potential mechanisms.
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