Publications by authors named "C Alidousty"
Background: Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environmental factors may contribute to regional differences in the mutation spectrum of European patients with iCCA, which are underrepresented in systematic genomic and transcriptomic studies of the disease.
View Article and Find Full Text PDFBackground: Sub-centrimetric papillary thyroid carcinomas usually have a good prognosis with a cancer specific survival of > 99%, however in up to 65% of patients, lymph node metastases can be observed. Molecular alterations in BRAF, TERT and TP53 are associated with worse clinicopathological outcome in patients with papillary thyroid carcinoma.
Material And Methods: Twenty-two cases of papillary thyroid carcinomas measuring ≤ 1 cm with synchronous lymph node metastases were examined regarding morphological patterns and immunohistochemical status of p53, Ki-67, and BRAF V600E status.
Article Synopsis
- In squamous cell carcinoma of the lung (LUSC), fewer targetable genetic alterations exist compared to lung adenocarcinoma (LUAD), prompting a study to analyze recurrent gene fusions in LUSC cases.
- A total of 1608 LUSC samples were examined using targeted next-generation sequencing, resulting in the discovery of gene fusions in about 3% of the cases, including known fusions like ALK::EML4 and new fusions like EGFR::VSTM2A.
- The study found that many LUSC patients have unstable genomes, suggesting that these gene fusions may not be the main drivers of cancer and caution is needed when interpreting new fusions in the context of
Article Synopsis
- More than 99% of cervical cancers and 40% of vulvar cancers are caused by a virus called HPV, especially types 16 and 18.
- Scientists are testing a new way to detect tiny bits of HPV DNA in blood to help monitor cancer treatment.
- They found that the amount of HPV DNA in the blood dropped a lot after treatment, indicating that this method could help doctors see if the treatment is working, especially for more advanced cancer cases.
MET amplifications (METamp) occur in 5% of NSCLC and represent in most case mechanisms of resistance to ALK and/or EGFR-targeted therapies. METamp detection can be performed using different techniques, although Fluorescence In-Situ Hybridization (FISH) remains the gold-standard, especially in the context of subclonality. To date current evaluation algorithms of MET amplifications are time consuming.
View Article and Find Full Text PDF