Publications by authors named "C Alec Pollard"
Multiple genetic associations suggest a causative relationship between Th17-related genes coding for proteins, such as IL-17A, IL-23 and STAT3, and psoriasis. Further support for this link comes from the findings that neutralizing antibodies directed against IL-17A, IL-17RA and IL-23 are efficacious in diseases like psoriasis, psoriatic arthritis and ankylosing spondylitis. RORγt is a centrally positioned transcription factor driving Th17 polarization and cytokine secretion and modulation of RORγt may thus provide additional benefit to patients.
View Article and Find Full Text PDFFood insecurity (FI) is a serious public health concern in economically developed countries, mainly due to unequal resource distribution. Identifying social vulnerability factors (i.e.
View Article and Find Full Text PDFHigh-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.
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- Sleep Related Painful Erections (SRPE) are REM sleep parasomnias that can severely affect sleep quality and daily functioning, prompting the development of a specialized diagnostic and treatment pathway.
- Diagnostic measures included a thorough review of patient history, clinical examinations, and various tests to identify other causes of penile pain, leading to a structured approach that involved medications, sleep studies, and pelvic floor therapy.
- Out of 20 patients treated, 70.6% experienced symptom relief, with significant improvements seen in sleep quality and pelvic floor assessments, highlighting the effectiveness of this comprehensive management plan.
Article Synopsis
- Neurodegenerative diseases like Alzheimer's are on the rise due to an aging population and lack of effective early treatments, making early detection crucial for better outcomes.
- Current diagnostics primarily focus on observable symptoms and existing neuronal damage, while specific biomarkers for Alzheimer's are too narrow, and general biomarkers like NfL lack precise insights.
- Circulating cell-free DNA (cfDNA) shows promise as a minimally invasive early detection biomarker, providing both general and disease-specific information, but further research is essential to overcome technical challenges and establish its clinical use.