[Digital transformation in Honduras: an information system for surveillance of ESAVI/AESITransformação digital em Honduras: sistema de informações para a vigilância de ESAVI/EAIE].

In Honduras, health systems have been faced with a duty and a need to establish surveillance mechanisms in order to understand the pathways of health and disease in the population. The objective of this article is to describe the process of analysis and the strategies used during development of a robust information system for vaccine safety surveillance, which can also be replicated for other forms of surveillance. For this purpose, agile development methods and open-source tools were used to design and develop a baseline monitoring system, incorporating recognized standards for information coding, validation, and verification.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Exploring the role of fatty acid esters of hydroxy fatty acids in metabolic dysfunction-associated steatotic liver disease in morbidly obese women.

Background: Fatty acid esters of hydroxy fatty acids (FAHFAs) present potential beneficial effects that could offer valuable insights into metabolic and inflammatory diseases. However, few FAHFAs have been studied, and their role is unclear.

Aims: To assess FAHFA levels in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) associated with morbid obesity (MO) to explore the potential significance of FAHFAs under these conditions.

Radiological characterization related to lithology and risk assessment of bottled natural mineral water.

The enhancement of natural radioactivity in groundwater, specifically in natural mineral water, is related to the lithological formations through which water bodies or courses pass. Although natural mineral waters are exempt from monitoring for radioactive substances according to Council Directive 2013/51/EURATOM, this study focuses on the radiological characterization of natural mineral water under Spanish Royal Decree 3/2023. The water studied was taken from Catalan aquifers with different lithological characteristics (sedimentary, metamorphic or granitic) and is sold on local markets.