Publications by authors named "C Abe"
Article Synopsis
- Bipolar disorder is linked to brain structure changes possibly caused by inflammation in the central nervous system, and this study explores how inflammation biomarkers in cerebrospinal fluid (CSF) relate to these changes over time.
- The research involved 29 individuals with bipolar disorder and 34 healthy controls, examining inflammation markers like IL-6, IL-8, and YKL-40, and used MRI to measure brain changes in specific areas.
- Results showed that higher CSF IL-8 levels were related to reduced cortical thickness in those with bipolar disorder, while in healthy controls, YKL-40 predicted brain ventricle enlargement, indicating potential inflammation effects in both conditions.
Article Synopsis
- Long-duration spaceflight can stress the skeletal and immune systems, but the specific response mechanisms are still not fully understood.
- A study with mice on the ISS evaluated how different gravitational conditions (microgravity, lunar gravity, and Earth gravity) affected their bone, thymus, and spleen over 25-35 days.
- Results showed that while bone density loss in microgravity was mostly restored in Earth gravity, lunar gravity only offered partial recovery; microgravity also caused thymus shrinkage, partially reversible by both lunar and Earth gravity but with ongoing gene expression issues.
Although specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD. We obtained body mass index (BMI) and diffusion tensor imaging derived fractional anisotropy (FA) from 22 white matter tracts in 899 individuals with BD, and 1287 control individuals from 20 cohorts in the ENIGMA-BD working group.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how the vestibular system in mice adapts to changes in gravity, focusing on hypergravity conditions (2 G) and normal gravity (1 G).
- Male C57BL/6J mice were tested for vestibular function and gene expression after exposure to higher gravity, revealing significant dysfunction that lasted for several days but improved once back to normal gravity.
- Analysis identified changes in 212 genes, with 25 genes increasing in expression under hypergravity and reverting to baseline after returning to normal gravity, highlighting specific genes important for neural function and adaptation to gravitational changes.
Brain network hubs are highly connected brain regions serving as important relay stations for information integration. Recent studies have linked mental disorders to impaired hub function. Provincial hubs mainly integrate information within their own brain network, while connector hubs share information between different brain networks.
View Article and Find Full Text PDF