Publications by authors named "C Abbal"
RH1 incompatibility between mother and fetus can cause hemolytic disease of the fetus and newborn. In Switzerland, fetal genotyping from maternal blood has been recommended from gestational age 18 onwards since the year 2020. This facilitates tailored administration of RH immunoglobulin (RHIG) only to RH1 negative women carrying a RH1 positive fetus.
View Article and Find Full Text PDFUnlabelled: Essentials The long-term effects of VKORC1 and CYP2C9 variants on clinical outcomes remains unclear. We followed 774 patients ≥65 years with venous thromboembolism for a median duration of 30 months. Patients with CYP2C9 variants are at increased risk of death and non-major bleeding.
View Article and Find Full Text PDFArticle Synopsis
- This study compared two treatment regimens for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL): high-dose imatinib with reduced-intensity chemotherapy (arm A) versus standard imatinib/hyperCVAD therapy (arm B) in 268 patients.
- The results showed a higher complete remission rate in arm A (98%) compared to arm B (91%), but similar major molecular response rates (66% vs 64%) after two treatment cycles.
- Long-term follow-up indicated that while event-free survival and overall survival rates were similar between the two arms, allogeneic stem cell transplantation significantly improved relapse-free survival and overall survival, highlighting its value as a treatment option.
Selectins and their ligand P-selectin glycoprotein ligand-1 (PSGL-1) mediate leukocyte rolling along inflamed vessels. Cell rolling is modulated by selectin interactions with their ligands and by topographic requirements including L-selectin and PSGL-1 clustering on tips of leukocyte microvilli. Lipid rafts are cell membrane microdomains reported to function as signaling platforms.
View Article and Find Full Text PDF