Publications by authors named "C Aalkjaer"
Article Synopsis
- Prorenin and its receptor ((P)RR) play significant roles in the renin-angiotensin-aldosterone system, with (P)RR found in various body tissues, including blood vessels, but its impact on arterial contractility remains unclear.
- Research using rat mesenteric arteries identified key interactions of (P)RR with important proteins in vascular smooth muscle cells (VSMCs) and revealed that prorenin increases arterial contraction through the α1-adrenoreceptor, enhancing calcium release without engaging voltage-gated calcium channels.
- The study concluded that prorenin boosts arterial contractility by inhibiting BK channels and promoting intracellular calcium release, likely via a localized pH shift facilitated by (P)RR
In the vascular wall, the Na,K-ATPase plays an important role in the control of arterial tone. Through cSrc signaling, it contributes to the modulation of Ca2+ sensitivity in vascular smooth muscle cells. This review focuses on the potential implication of Na,K-ATPase-dependent intracellular signaling pathways in severe vascular disorders; ischemic stroke, familial migraine, and arterial hypertension.
View Article and Find Full Text PDFArticle Synopsis
- A new variant in the SLC4A3 gene has been linked to short QT syndrome (SQTS), but its significance in sudden cardiac death is still unclear.
- This study examined genetic variants in SQTS patients, finding disease-causing variants in 26% of those tested, primarily in the SLC4A3 gene.
- Results indicate that SLC4A3 variants lead to changes in heart activity, confirming the need to screen for these variants in SQTS and sudden cardiac death cases.
Aims: The aim of this study is to examine whether colchicine improves β adrenoceptor-mediated vasodilation in humans by conducting a double-blinded, placebo-controlled intervention study. Colchicine treatment has known beneficial effects on cardiovascular health and reduces the incidence of cardiovascular disease. Studies in isolated rodent arteries have shown that colchicine can enhance β adrenoceptor-mediated vasodilation, but this has not been determined in humans.
View Article and Find Full Text PDF