Pacemaker Implantation After Tricuspid Valve Surgery at a High-Volume Regional Reference Center.

Background: The rate of permanent pacemaker implantation after tricuspid valve (TV) operation is thought to be high, with some studies quoting rates of 20% to 30%. We identified the rate of pacemaker implantation after TV operation at a high-volume regional reference center to better characterize the contemporary risk of pacemaker.

Methods: All adult patients without preexisting pacemakers undergoing TV operation from 2011 to 2022 were included.

Unmasking the Environmental Costs of In-Person General Surgery Residency Interviews.

Objective: As COVID-19 restrictions are eased, there has been a lively debate on whether residency recruitment interviews should be held virtually or in-person. However, environmental impact has rarely been a focus of this debate and only by inference from limited survey data. In this study, we aimed to estimate the carbon emissions generated from air-travel versus in-person interviews in the general surgery residency recruitment.

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling.

Circulating tumor cells (CTCs) drive metastasis, the leading cause of death in individuals with breast cancer. Due to their low abundance in the circulation, robust CTC expansion protocols are urgently needed to effectively study disease progression and therapy responses. Here we present the establishment of long-term CTC-derived organoids from female individuals with metastatic breast cancer.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.