Broad-spectrum downregulation of inflammatory cytokines by polydopamine nanoparticles to protect the injured spinal cord.

Acute neuroinflammation, which is notably characterized by a significant elevation in pro-inflammatory cytokines and chemokines, often rapidly develops following a traumatic spinal cord injury and exacerbates damage in the lesion area. This study addresses the limitations inherent in strategies that regulate only a single or a few cytokines, which are often insufficient to counteract the progression of secondary injuries. We explore the use of polydopamine nanoparticles as a broad-spectrum immunomodulator, capable of capturing by adsorption a wide range of cytokines and thereby effectively suppressing neuroinflammation.

Nanoplastics as competitors of natural colloids in the environment: The case of gadolinium complexes.

This study investigates whether nanoplastics are significant contributor of rare earth elements (Gd) transportation under environmental conditions. Important effects of nanoplastic concentration, Gd concentration, complexation with organic ligands, pH, ionic strength and occurrence of natural colloids competitor were studied thanks to an experimental design combining incubation follow by ultrafiltration and ICPMS analyses. In particular, we observed that even in sea water, about half of the gadolinium can be adsorbed on nanoplastics.

Identifying rice varieties for mitigating methane and nitrous oxide emissions under intermittent irrigation.

Context Or Problem: Most of the research evaluating rice varieties, a major global staple food, for greenhouse gas (GHG) mitigation has been conducted under continuous flooding. However, intermittent irrigation practices are expanding across the globe to address water shortages, which could alter emissions of methane (CH) compared to nitrous oxide (NO) for reducing overall global warming potential (GWP). To develop climate-smart rice production systems, it is critical to identify rice varieties that simultaneously reduce CH and NO emissions while maintaining crop productivity under intermittent irrigation.

Computational design for enantioselective CO capture: asymmetric frustrated Lewis pairs in epoxide transformations.

Carbon capture and utilisation (CCU) technologies offer a compelling strategy to mitigate rising atmospheric carbon dioxide levels. Despite extensive research on the CO insertion into epoxides to form cyclic carbonates, the stereochemical implications of this reaction have been largely overlooked, despite the prevalence of racemic epoxide solutions. This study introduces an in silico approach to design asymmetric frustrated Lewis pairs (FLPs) aimed at controlling reaction stereochemistry.

Oxenoid Reactivity Enabled by Targeted Photoactivation of Periodate.

The chemistry of low-valent intermediates continues to inspire new modes of reactivity across synthetic chemistry. But while the generation and reactivity of both carbenes and nitrenes are well-established, difficulties in accessing oxene, their oxygen-based congener, has severely hampered its application in synthesis. Here, we report a conceptually novel approach towards oxenoid reactivity through the violet-light photolysis of tetrabutylammonium periodate.