Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters.

The effects of mirex, two monohydrogen and two dihydrogen mirex derivatives, and chlordecone on several hepatic parameters were studied 2 days following a single oral dose of 100 mg/kg in female rats. All compounds increased microsomal cytochrome P-450 content, NADPH-cytochrome c reductase activity, and hepatic ascorbic acid concentration. Microsomal protein concentration was generally increased.

Lipid catabolism of cultivated treponemes.

Treponema require long-chain fatty acids for growth in vitro. Serum, added to culture media, provides a source of long-chain fatty acids. These fatty acids, however, are esterified to triglycerides, phospholipids, and cholesterol.