Publications by authors named "C A Schumann"
Objective: Theories of amygdala function are central to our understanding of psychiatric and neurodevelopmental disorders. However, limited knowledge of the molecular and cellular composition of the amygdala impedes translational research aimed at developing new treatments and interventions. The aim of this study was to characterize and compare the composition of amygdala cells to help bridge the gap between preclinical models and human psychiatric and neurodevelopmental disorders.
View Article and Find Full Text PDF[FeFe]-hydrogenases function as both H catalysts and sensors. While catalysis is well investigated, details regarding the H sensing mechanism are limited. Here, we relate protein structure changes to H sensing, similar to light-driven bio-sensors.
View Article and Find Full Text PDFArticle Synopsis
- - The primate brain has evolved with significant changes in key structures, particularly the prefrontal cortex and its connections with circuits like the striatum and amygdala, enhancing executive functions and social cognition.
- - This review emphasizes how recent evolutionary changes in inhibitory GABAergic circuits may contribute to the development of neurodevelopmental disorders by affecting normal brain development.
- - The complexity of inhibitory brain systems is linked to vulnerabilities in conditions like autism and schizophrenia, with changes seen in specific syndromes like Williams syndrome shedding light on these mechanisms.
Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester.
View Article and Find Full Text PDFObjectives: In order to evaluate the impact of the surfactant of choice selection, primary end points were to compare the average number of doses per patient, need for mechanical ventilation on day 3, hospital length of stay, and in-hospital mortality between calfactant and poractant alfa in preterm infants with respiratory distress syndrome (RDS). Secondary outcomes included administration complications, development of bronchopulmonary dysplasia (BPD), and estimated average per patient cost among the study population.
Methods: A retrospective chart review was performed at a level IV neonatal intensive care unit between January 2020 and December 2021 to compare the efficacy, safety, and pharmacoeconomic outcomes -following a surfactant of choice switch from calfactant to poractant alfa in preterm infants with RDS.