Genomic analysis of isolated from surface water and animal sources in Chile reveals new T6SS effector protein candidates.

Type VI Secretion Systems (T6SS), widely distributed in Gram-negative bacteria, contribute to interbacterial competition and pathogenesis through the translocation of effector proteins to target cells. harbor 5 pathogenicity islands encoding T6SS (SPI-6, SPI-19, SPI-20, SPI-21 and SPI-22), in which a limited number of effector proteins have been identified. Previous analyses by our group focused on the identification of candidate T6SS effectors and cognate immunity proteins in genomes deposited in public databases.

SEN1990 is a predicted winged helix-turn-helix protein involved in the pathogenicity of serovar Enteritidis and the expression of the gene in the SPI-17.

Excisable genomic islands (EGIs) are horizontally acquired genetic elements that harbor an array of genes with diverse functions. ROD21 is an EGI found integrated in the chromosome of serovar Enteritidis ( ser. Enteritidis).

Identification and distribution of new candidate T6SS effectors encoded in Pathogenicity Island 6.

The type VI secretion system (T6SS) is a contact-dependent contractile multiprotein apparatus widely distributed in Gram-negative bacteria. These systems can deliver different effector proteins into target bacterial and/or eukaryotic cells, contributing to the environmental fitness and virulence of many bacterial pathogens. harbors five different T6SSs encoded in different genomic islands.

Transfer of T6SS from Gallinarum to Typhimurium Lacking T6SS Complements its Colonization Defect in Mice.

genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS) contributes to Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS) of Gallinarum contributes to chicken colonization. Interestingly, the T6SS of Gallinarum complemented the defect in chicken colonization of a Typhimurium strain that lacks the T6SS, suggesting that both T6SSs are interchangeable.

Identification of Type VI Secretion Systems Effector Proteins That Contribute to Interbacterial Competition in Dublin.

The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells a contractile mechanism. While some effector proteins specifically target bacterial or eukaryotic cells, others can target both types of cells (trans-kingdom effectors). In , five T6SS gene clusters have been identified within pathogenicity islands SPI-6, SPI-19, SPI-20, SPI-21, and SPI-22, which are differentially distributed among serotypes.