Publications by authors named "C A Remme"
A sodium current (I) reduction occurs in the setting of many acquired and inherited conditions and is associated with cardiac conduction slowing and increased arrhythmia risks. The sodium channel blocker mexiletine has been shown to restore the trafficking of mutant sodium channels to the membrane. However, these studies were mostly performed in heterologous expression systems using high mexiletine concentrations.
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- The study investigates how genetic background and age affect the severity of heart disease in a mouse model with SCN5A mutations, specifically focusing on the Scn5a1798insD/+ mice.
- Results showed that aged mutant mice, particularly those from the 129P2 strain, exhibited more severe electrical dysfunctions and structural changes compared to the FVB/N strain, including prolonged conduction times and increased risk of arrhythmias.
- The findings suggest that both age and genetic background are important factors in the expression of cardiac disease in SCN5A mutation patients, highlighting the need for tailored approaches in assessing and managing these conditions.
Aims: The microtubule (MT) network plays a major role in the transport of the cardiac sodium channel Nav1.5 to the membrane, where the latter associates with interacting proteins such as dystrophin. Alterations in MT dynamics are known to impact on ion channel trafficking.
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