Publications by authors named "C A Raji"
Objective: This study investigated how obesity, BMI ≥ 30 kg/m, abdominal adiposity, and systemic inflammation relate to neuroinflammation using diffusion basis spectrum imaging.
Methods: We analyzed data from 98 cognitively normal midlife participants (mean age: 49.4 [SD 6.
Plasma phosphorylated-tau 217 (p-tau217) is currently the most promising biomarker for reliable detection of Alzheimer's disease (AD) pathology. Various p-tau217 assays have been developed, but their relative performance is unclear. We compared key plasma p-tau217 tests using cross-sectional and longitudinal measures of amyloid-β (Aβ)-PET, tau-PET, and cognition as outcomes, and benchmarked them against cerebrospinal fluid (CSF) biomarker tests.
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- Brain MRI with volumetric quantification helps distinguish between neurocognitive disorders by detecting brain atrophy not visible in standard visual assessments.
- A study with 137 participants revealed MRI volumetry's effectiveness in diagnosing traumatic brain injury and various forms of Alzheimer's disease, highlighting significant differences in brain volumes among the conditions.
- The results showed that the diagnostic accuracy was highest for traumatic brain injury, with specific brain regions identified as crucial predictive features for distinguishing between the disorders.
Article Synopsis
- * The paper aims to help radiologists by discussing MRI protocols, workflows, and reporting practices for monitoring amyloid-related imaging abnormalities (ARIA).
- * Key topics include FDA guidelines for ARIA evaluation, standard MRI sequences, patient imaging scenarios, the radiologist's role in treatment, and results from a 2023 survey on dementia imaging practices.
Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis.
J Neurol Neurosurg Psychiatry
August 2024
Background: Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via multiple mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests of daily and intermittent CR (iCR) in people with MS (pwMS) showed improvements in fatigue and well-being measures.
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