Bacterial clustering amplifies the reshaping of eutrophic plumes around marine particles: A hybrid data-driven model.

Multifaceted interactions between marine bacteria and particulate matter exert a major control over the biogeochemical cycles in the oceans. At the microbial scale, free-living bacteria benefit from encountering and harnessing the plumes around nutrient-releasing particles, like phyto-plankton and organic aggregates. However, our understanding of the bacterial potential to reshape these eutrophic microhabitats remains poor, in part because of the traditional focus on fast-moving particles that generate ephemeral plumes with lifetime shorter than the uptake timescale.

The Effectiveness of Atezolizumab in Metastatic Large Cell Neuroendocrine Carcinoma of the Lungs: Insights from the LANCE Pilot Study.

Background: Large cell neuroendocrine carcinoma (LCNEC) presents significant treatment challenges due to its rarity and limited therapeutic options. The LANCE study was designed to explore the survival benefits of incorporating atezolizumab in chemotherapy for metastatic LCNEC.

Methods: In this non-randomized study, patients with metastatic LCNEC were prospectively enrolled and assigned to receive either standard chemotherapy plus atezolizumab followed by maintenance with atezolizumab or standard chemotherapy alone.

Impact of Microbial Uptake on the Nutrient Plume around Marine Organic Particles: High-Resolution Numerical Analysis.

The interactions between marine bacteria and particulate matter play a pivotal role in the biogeochemical cycles of carbon and associated inorganic elements in the oceans. Eutrophic plumes typically form around nutrient-releasing particles and host intense bacterial activities. However, the potential of bacteria to reshape the nutrient plumes remains largely unexplored.

Fibroblasts in intestinal homeostasis, damage, and repair.

The mammalian intestine is a self-renewing tissue that ensures nutrient absorption while acting as a barrier against environmental insults. This is achieved by mature intestinal epithelial cells, the renewing capacity of intestinal stem cells at the base of the crypts, the development of immune tolerance, and the regulatory functions of stromal cells. Upon intestinal injury or inflammation, this tightly regulated mucosal homeostasis is disrupted and is followed by a series of events that lead to tissue repair and the restoration of organ function.