Publications by authors named "C A O'Morain"
Article Synopsis
- Bismuth quadruple therapies (BQTs) have been effective in treating Helicobacter pylori infections in Europe, particularly in the face of antibiotic resistance, with notable use increasing from 8.6% in 2013 to 39% in 2021.
- An analysis of data from nearly 50,000 patients indicated that the single-capsule BQT was the most common regimen and achieved over 90% effectiveness with certain combinations.
- Key factors that improved treatment success included adherence to the regimen, use of high-dose proton pump inhibitors, and implementing the therapy as a first-line treatment.
Article Synopsis
- A study examined how different reasons for testing for Helicobacter pylori (H. pylori) affect treatment prescriptions and their success rates across Europe from 2013 to 2023.
- Out of 53,636 cases, the most common reasons for testing included dyspepsia with normal endoscopy and various types of ulcers, with treatment effectiveness ranging from 87% to 91% based on the indication.
- Patients with ulcers and preneoplastic lesions experienced higher treatment success and compliance, while those tested for dyspepsia had higher rates of adverse effects.
Current and Future Perspectives on the Management of : A Narrative Review.
Antibiotics (Basel)
June 2024
The prevalence of , a pathogen, has decreased globally in the last decade. To date, the management of has focused on a reactive approach, whereby those diagnosed are treated with antimicrobials and acid suppression in combination. This review article provides an overview of the shift in the management of from a reactive approach towards a proactive 'screen and treat' approach; the article reflects the current pharmacological landscape for treatment by exploring similarities such as the first-line prescription of quadruple therapy in most countries and provides a summary table of the best practice guidance from Europe, Asia, and North America.
View Article and Find Full Text PDFArticle Synopsis
- - National and international increases in resistance to antimicrobials for treating Helicobacter pylori (H. pylori), particularly high clarithromycin resistance levels in Ireland, necessitated a reassessment of treatment strategies.
- - The Irish H. pylori working group (IHPWG) conducted a review using the 'GRADE' approach to develop updated management recommendations based on the latest research findings.
- - Key recommendations include using bismuth quadruple therapy as the first-line treatment in unclear or confirmed clarithromycin resistance cases, and reserving clarithromycin triple therapy for cases with confirmed susceptibility, along with specific strategies for second-line and rescue therapies.
Background: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy.
Objective: To determine which factors influence compliance with treatment.