Publications by authors named "C A Morse"
[F]SF51 is a novel radioligand for imaging translocator protein 18 kDa (TSPO) that previously displayed excellent imaging properties in nonhuman primates. This study assessed its performance in human brain and its dosimetry. Seven healthy participants underwent brain PET imaging to measure TSPO binding using a two-tissue compartment model (2TCM) to calculate total distribution volume ().
View Article and Find Full Text PDFThe association between smoking/vaping habits and self-reported respiratory symptoms.
Multidiscip Respir Med
October 2024
Background: Smoking is well known for its harmful effect on the respiratory system, but whether vaping is less harmful is unknown. Therefore, the aim of this study was to assess the association of smoking/vaping habits with self-reported respiratory symptoms in vapers and cigarette smokers.
Methods: An online survey was developed and shared on different vaping and smoking social media platforms and communities.
Antipolyphosphate monoclonal antibodies derived from autoimmune mice.
Res Pract Thromb Haemost
August 2024
Background: Inorganic polyphosphates (polyPs) are linear chains of phosphates that accelerate blood clotting. Targeting polyP has been shown to reduce thrombosis.
Objectives: To identify and characterize anti-polyP monoclonal antibodies that could be used as analytical tools and as antithrombotic agents.
Article Synopsis
- The cAMP cascade is important for regulating alcohol behaviors, showing different effects with short-term vs. long-term alcohol consumption.
- PDE4 is the main enzyme that breaks down cAMP in the brain, and a specific subtype, PDE4B, is linked to alcohol and substance use disorders.
- The study used PET imaging in rats to show that acute alcohol increases PDE4B activity, while chronic alcohol decreases it, suggesting that PDE4B imaging could help understand and treat alcohol use disorders in humans.
Background: Vitamin D insufficiency (25OHD, 50-75 nmolˑl) is a common issue within healthy adults and elite athletes and is associated with decreased musculoskeletal health and performance. However, few studies have identified the prevalence and risk factors associated with vitamin D insufficiency within elite Para-Athletes.
Methods: An electronic search was completed on the 5th January 2023 and updated on the 21st June 2024, searching Web of Science, PubMed, Scopus, Cochrane Library and EASY (originally OpenGrey).