Publications by authors named "C A Minetti"

Article Synopsis
  • * Researchers analyzed 416 isolates and found that fluoroquinolone-resistant (FQR) strains increased significantly, reaching 38% in S. flexneri and 80% in S. sonnei by 2022.
  • * Notably, S. sonnei from men were much more likely to be FQR, and genomic analysis identified two major resistant genetic clusters linked to high transmission rates among men who have sex with men, emphasizing the need for better surveillance.
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Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix interaction. However, little is known about the influence of altered gravity on hydrogel properties.

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In the process of tissue engineering, several types of stresses can influence the outcome of tissue regeneration. This outcome can be understood by designing hydrogels that mimic this process and studying how such hydrogel scaffolds and cells behave under a set of stresses. Here, a hydrogel formulation is proposed to create biomimetic scaffolds suitable for fibroblast cell culture.

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Aristolochic acids I and II (AA-I/II) are carcinogenic principles of Aristolochia plants, which have been employed in traditional medicinal practices and discovered as food contaminants. While the deleterious effects of AAs are broadly acknowledged, there is a dearth of information to define the mechanisms underlying their carcinogenicity. Following bioactivation in the liver, N-hydroxyaristolactam and N-sulfonyloxyaristolactam metabolites are transported via circulation and elicit carcinogenic effects by reacting with cellular DNA.

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