Response of neuronal populations to phase-locked stimulation: model-based predictions and validation.

Modulation of neuronal oscillations holds promise for the treatment of neurological disorders. Nonetheless, conventional stimulation in a continuous open-loop manner can lead to side effects and suboptimal efficiency. Closed-loop strategies such as phase-locked stimulation aim to address these shortcomings by offering a more targeted modulation.

Revisiting the druggable genome using predicted structures and data mining.

Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space is also constrained by existing compound libraries and phenotypic assay conditions.

Heat Strokes in Active-Duty Military.

Introduction: Military service members are at risk of heat stroke, particularly due to physical exertion during training and tasks. Due to the serious nature and potentially fatal consequences of heat stroke, it is important to understand trends over time and among subgroups of service members in diagnoses of heat stroke. We aimed to replicate and extend recent work by Williams and Oh1 by examining the incidence of heat stroke in military service members from 2016 to 2021 and performing subgroup comparisons for sex, age, race, marital status, pay grade, and service branch.

Minimal variation between surgeons in online patient-reported ratings: A meaningless metric? - A retrospective analysis of physician reviews.

There is limited information available when selecting a physician. Many patients now rely on physician-review websites to help make their decision. Additionally, there has been increasing emphasis on patient satisfaction scores and reviews as a metric for compensation.

Unstable coronary artery plaque features in humans are associated with higher frequency of circulating CD56bright Natural Killer Cells.

Unstable human artery plaques can suddenly rupture, leading to MI or stroke. Identification of blood markers associated with unstable plaque features is clearly needed. Humans with symptomatic carotid atherosclerotic plaques have increased plaque infiltration of CD56bright Natural Killer (NK) cells, yet whether subjects with unstable coronary artery plaque features have increased frequencies of circulating CD56bright NK cells is unknown.