Publications by authors named "C A McKenney"
Article Synopsis
- UV radiation can harm both DNA and RNA in cells, causing different stress responses when cells are damaged.
- Researchers studied how cells react to UV damage using various scientific methods to understand the timing and effects of these responses.
- They found that a specific protein called ZAK controls cell death after UV damage and is regulated by two different feedback systems to help maintain balance in the cells.
Article Synopsis
- The growing number of wheelchair users in the U.S. emphasizes the need for reliable and affordable wheelchair maintenance and repair services for improving quality of life.
- The study introduces a workshop program aimed at teaching essential wheelchair maintenance skills to bike shop employees, healthcare professionals, and wheelchair users, which showed increased confidence in these skills post-training.
- Community workshops can enhance wheelchair maintenance abilities and potentially address the accessibility gap in repair services, with further research needed to evaluate long-term benefits.
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G) to synthesis (S) phase transition of the cell cycle by responding to mitogen signaling, promoting E2F transcription and inhibition of the anaphase-promoting complex. We found that this mechanism was still required in G-arrested cells to prevent cell cycle exit after the S phase.
View Article and Find Full Text PDFWhole-genome duplication (WGD) is a frequent event in cancer evolution that fuels chromosomal instability. WGD can result from mitotic errors or endoreduplication, yet the molecular mechanisms that drive WGD remain unclear. Here, we use live single-cell analysis to characterize cell-cycle dynamics upon aberrant Ras-ERK signaling.
View Article and Find Full Text PDFTo unveil presently inscrutable details of the origins of our universe imprinted in the cosmic microwave background, future experiments in the millimeter and submillimeter range are focusing on the detection of fine features, which necessitate large and sensitive detector arrays to enable multichroic mapping of the sky. Currently, various approaches for coupling light to such detectors are under investigation, namely, coherently summed hierarchical arrays, platelet horns, and antenna-coupled planar lenslets. The last option offers increased bandwidth and a simpler fabrication while maintaining the desired optical performance.
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