Publications by authors named "C A McHugh"
Article Synopsis
- This study examined how playing multiple seasons of rugby affects serum S100B levels in male professional players and the acute impact of concussion on these levels.
- Researchers collected blood samples during different seasons of play and after concussions to measure S100B concentrations using an ELISA assay.
- The results showed that while S100B levels remained stable across seasons, they significantly increased immediately after concussions, but returned to pre-season levels by the end of the season, suggesting S100B could be a valuable tool in managing sports-related concussions.
The middle ear transforms sound from low-impedance external air to high-impedance cochlear fluid. However, the human stapes - the input to the cochlea - has been reported to have minimal or no motion above ~ 4 kHz. For decades, this lack of observed high-frequency stapes motion has been puzzling, as it is inconsistent with our ability to hear up to 20 kHz.
View Article and Find Full Text PDFHuntington's disease (HD) arises from a CAG expansion in the () gene beyond a critical threshold. A major thrust of current HD therapeutic development is lowering levels of mutant mRNA (m) and protein (mHTT) with the aim of reducing the toxicity of these product(s). Human genetic data also support a key role for somatic instability (SI) in 's CAG repeat - whereby it lengthens with age in specific somatic cell types - as a key driver of age of motor dysfunction onset.
View Article and Find Full Text PDFCrystal clear: the impact of crystal structure in the development of high-performance organic semiconductors.
Acta Crystallogr C Struct Chem
November 2024
Objective: We present the "UmboMic," a prototype piezoelectric cantilever microphone designed for future use with totally-implantable cochlear implants.
Methods: The UmboMic sensor is made from polyvinylidene difluoride (PVDF) because of its low Young's modulus and biocompatibility. The sensor is designed to fit in the middle ear and measure the motion of the underside of the eardrum at the umbo.