Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition.

Radiopharmaceutical therapy (RPT) enhances tumor response to immune checkpoint inhibitors (ICI) in preclinical models, but the effects of different radioisotopes have not been thoroughly compared. To evaluate mechanisms of response to RPT+ICI, we used NM600, an alkylphosphocholine selectively taken up by most tumors. Effects of Y-, Lu-, and Ac-NM600 + ICIs were compared in syngeneic murine models, B78 melanoma (poorly immunogenic) and MC38 colorectal cancer (immunogenic).

Evaluation of Marburg Virus Medical Countermeasures in Guinea Pigs.

Various animal models have been established to gain a better understanding of the pathogenesis of Marburg virus (MARV) and Ravn virus (RAVV), and to develop medical countermeasures (MCMs) against them. Of these models, which range from rodents to nonhuman primates (NHPs), the macaque model most closely mimics the severe disease displayed in humans. Nevertheless, rodent models mirror many key aspects of human infection and are frequently used for the initial assessment of experimental vaccines and treatments.

Controls on fluvial sediment evacuation following an earthquake-triggered landslide: Observations from LiDAR time series.

Catastrophic sediment overloading of mountain streams in response to coseismic landsliding causes river systems to fundamentally reorganize their morphology and sediment transporting characteristics, influencing sediment yields, bedrock incision, and the coupling between erosion and tectonics. A sequence of 13 airborne LiDAR surveys of an alpine tributary of the Hāpuku River, New Zealand, reveals patterns of sediment mass balance change over 5 years following delivery of 6.6 million cubic meters of landslide debris during the 2016 magnitude 7.

Adaptively triggered comparisons enhance perceptual category learning: evidence from face learning.

Categorical learning is important and often challenging in both specialized domains, such as medical image interpretation, and commonplace ones, such as face recognition. Research has shown that comparing items from different categories can enhance the learning of perceptual classifications, particularly when those categories appear highly similar. Here, we developed and tested novel adaptively triggered comparisons (ATCs), in which errors produced during interactive learning dynamically prompted the presentation of active comparison trials.