Publications by authors named "C A Markarian"
(FL) is a well-known optimization problem that asks to optimally place facilities so as to serve clients at various locations, requesting a facility service, with minimum possible costs. Many variants of FL have been known, appearing as sub-problems in many applications in computer science, management science, and operations research. Most FL models studied thus far assume that clients need to be served by connecting each to one facility.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- Adipose-derived stromal cells (ASCs) are typically isolated using collagenase, but this study explored more cost-effective methods for their extraction.
- Nine protocols, including various enzyme digestions and centrifugation, were compared based on several criteria like isolation rate and differentiation capacity.
- The trypsin digestion method effectively maintained ASCs with similar characteristics to those isolated by collagenase but showed significantly superior osteogenic differentiation, making it a promising approach for bone tissue engineering.