Publications by authors named "C A Marboe"
Background: Proteomic phenotyping can provide insights into rejection pathophysiology, novel biomarkers, and therapeutic targets.
Methods: Within the prospective, multicenter Genomic Research Alliance for Transplantation study, 181 proteins were evaluated from blood drawn at the time of endomyocardial biopsy; protein fold change, logistic regression, and pathway analyses were conducted, with protein discovery adjusted for a 5% false discovery rate.
Results: Among 104 adult heart transplant patients (31% female sex, 53% Black race, median age 52 y), 74 had no rejection, 18 developed acute cellular rejection (ACR), and 12 developed antibody-mediated rejection (AMR).
Article Synopsis
- Coccidioidomycosis is a serious fungal infection that can be transmitted through organ transplantation, with a review of cases from 2013 to 2022 revealing significant risks.
- Seven deceased donors transmitted the infection to eight recipients, resulting in a 40% infection rate among organ recipients.
- The study highlights the importance of thorough donor evaluations and antifungal treatment to reduce the high mortality associated with these infections post-transplant.
Article Synopsis
- Heart transplant patients with donor-specific antibodies (DSAs) face a higher risk of rejection, but some do not show antibody-mediated rejection despite having graft dysfunction.
- A study involved 216 participants undergoing serial evaluations like endomyocardial biopsy (EMB) and echocardiograms to understand the relationship between DSAs, rejection types, and long-term outcomes.
- Results indicated that both antibody-mediated rejection (pAMR+) and DSA-related left ventricle dysfunction significantly correlated with increased mortality and prolonged heart dysfunction, particularly if they occurred within the first six months after transplant.
Background: There is significant variability among pathologists in the histopathological interpretation of the endomyocardial biopsy (EMB) for acute cellular rejection (ACR), and assessment of variability in the interpretation of antibody-mediated rejection (AMR) has not been reported. In contemporary practice, the strategy of allograft surveillance with donor-derived cell-free DNA (dd-cfDNA) compared to EMB has not been compared with a focus on long-term clinical outcomes beyond acute rejection (AR).
Methods: The Genomic Research Alliance for Transplantation is a multicenter, prospective cohort study that enrolled patients from 2015 to 2020.
Among the post-transplantation complications that patients may encounter, the transmission of a donor-derived malignant neoplasm is uncommon but potentially life threatening. The determination of donor versus recipient origin is essential particularly in the setting of multiple transplant recipients from the donor. Advances in molecular biology now allow accurate discrimination utilizing routine tissue samples in a timely and cost-effective manner.
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