Staff perceptions and experiences of using Key Word Signing with children with Down syndrome and their peers in the first year of mainstream primary education.

Background: Key Word Signing (KWS) is one system that can be used to support the communication needs of children with Down syndrome (DS) who attend mainstream school. The success of KWS in schools is mediated by staff experiences and perceptions of KWS. The current study is one of the first to explore KWS use in mainstream schools.

Clinician Perspectives Highlight the Need for Early Dyadic Coping Skills for People Living With Amyotrophic Lateral Sclerosis.

Context: A diagnosis of ALS can be challenging, and many people find ways to adapt. At the same time, emotional distress can arise early after an ALS diagnosis even when high quality multidisciplinary care is provided. When emotional distress occurs, it can become chronic over time, and can affect both the person living with ALS and their care-partner (together called a dyad).

Draft genome sequences of strains isolated from ocular surface of CD36-knockout mice (B6.129S1-/J) with keratitis.

Three strains were cultured from the eyes of CD36-knockout mice (B6.129S1-/J) with and without keratitis housed at a biomedical research institute. Bacteria were sequenced using Illumina MiSeq technology for subsequent phylogenetic characterization and identification of virulence factor genes conferring pathogenic potential.

Adverse Events as a Function of Biological Sex in a Multicenter Clinical Trial of Melanoma Vaccines.

Biological females experience more autoimmune disease than males and more treatment-related adverse events (TRAEs) after immune checkpoint blockade therapy. However, little is known about sex-related differences in TRAEs after cancer vaccines. : The Mel44 clinical trial (NCT00118274) enrolled 167 eligible patients with high-risk melanoma to treatment with either of two melanoma multipeptide vaccines.