Publications by authors named "C A Linker"
The generation of complex structures during embryogenesis requires the controlled migration and differentiation of cells from distant origins. How these processes are coordinated and impact each other to form functional structures is not fully understood. Neural crest cells migrate extensively giving rise to many cell types.
View Article and Find Full Text PDFCoordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression affects migration, and vice versa, remains largely unknown. We address these questions by combining in silico modelling and in vivo experimentation in the zebrafish trunk neural crest (TNC).
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- - The study investigated how respiratory rate (RR) in patients with cystic fibrosis (pwCF) relates to factors like antibiotic treatment, exacerbation status, lung function (FEV1), and inflammation (CRP) over a one-year period.
- - Researchers enrolled 47 pwCF, measuring RR and heart rate during hospital stays, noting that patients with exacerbations had higher RR compared to those without and that RR decreased for both groups by discharge.
- - The results indicated a correlation between RR and FEV1 (lung function) as well as a positive correlation with CRP (marker of inflammation), suggesting that monitoring RR could provide valuable insights into the clinical status of pwCF during treatment.
A multicentre open-label study of apremilast in palmoplantar pustulosis (APLANTUS).
J Eur Acad Dermatol Venereol
October 2021
Background: Palmoplantar pustulosis (PPP) is a chronic skin disease with painful erythematous scaly or crusty lesions and pustules on the palms and soles. Apremilast is a phosphodiesterase 4 inhibitor that has proven effective in the therapy of psoriasis, psoriatic arthritis and in oral ulcers associated with Behcet's disease.
Objective: To explore the efficacy of apremilast in PPP.
Purpose: In our study we aimed to analyze sleep variability and activity in patients with cystic fibrosis (CF) during their hospital stay.
Methods: Forty-three CF patients were recruited and have been divided into two subgroups: exacerbated (n = 18) and non-exacerbated (n = 25). During the course of their hospital stay we used VitaLog, a minimal-impact biomotion device, in order to determine total sleep time (TST), time in bed (TIB), sleep efficiency (SE) and intra patient standard deviation (IPSD) of TST.