Publications by authors named "C A Labarrere"
In Senegal, Coxiella burnetii, which causes Q fever, has often been identified in ticks and humans near livestock, which are considered to be reservoirs and main sources of infection. We describe the emergence of C. burnetii in rodents, not previously known to carry this pathogen, and describe 2 new genotypes.
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- Many critical health issues, like COPD, heart disease, cancer, and COVID-19, are linked to oxidative stress and inflammation that lower levels of glutathione (GSH), a vital antioxidant in our cells.
- GSH plays a key role in maintaining cellular health by balancing oxidative stress and activating protective pathways that regulate antioxidant and immune responses.
- Lower GSH levels are associated with inflammatory diseases and increased severity of COVID-19, suggesting that therapies aimed at boosting GSH could be crucial for improving outcomes and managing these health conditions.
Article Synopsis
- - SARS-CoV-2, the virus responsible for COVID-19, is associated with high mortality rates due to risk factors that trigger oxidative stress, specifically an overload of reactive oxygen species (ROS) that deplete glutathione (GSH) levels.
- - GSH is a crucial antioxidant that helps regulate cellular processes and protect against oxidative damage, with its levels influencing the body's immune and inflammatory responses.
- - The imbalance between GSH and its oxidized form (GSSG) serves as an indicator of cellular health, and oxidative stress is a key factor in SARS-CoV-2 infection, activating various immune pathways that can worsen disease severity.
Pattern Recognition Proteins: First Line of Defense Against Coronaviruses.
Front Immunol
October 2021
The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan, China, has become a worldwide pandemic affecting almost 204 million people and causing more than 4.3 million deaths as of August 11 2021. This pandemic has placed a substantial burden on the global healthcare system and the global economy.
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