Publications by authors named "C A L Jonker"
Aim of the study To assess the incidence and types of complications and patient-reported outcomes in pediatric patients with therapy-resistant constipation or fecal incontinence (FI) without constipation who underwent Chait TrapdoorTM cecostomy (CTC). The findings contribute to the discussion on selecting the optimal antegrade continence (ACE) procedure for this population. Materials and Methods A retrospective review was conducted on all pediatric patients with therapy-resistant constipation or FI without constipation who underwent a CTC procedure at our tertiary referral center between 2009 and 2023.
View Article and Find Full Text PDFArticle Synopsis
- - There’s a rising trend in drug development to incorporate real-world evidence (RWE) during the pre-marketing phase, influenced by initiatives like DARWIN EU® and regulator-initiated observational studies.
- - An expert meeting held by the Regulatory Science Network Netherlands in 2022 addressed key aspects of these studies, including transparency, independence, and engagement with stakeholders.
- - The authors stress the significance of reproducibility and collaborative efforts among stakeholders to effectively implement regulator-initiated studies for a better European RWE framework in regulatory decisions.
Background: Despite optimal conservative and medical treatment, some children with functional constipation (FC) continue to experience symptoms. Antegrade continence enema (ACE) surgery has been suggested as the primary surgical option after less invasive pharmacological and non-pharmacological interventions have not been effective. The purpose of this systematic review was to assess the outcomes of ACE for children with FC.
View Article and Find Full Text PDFPurpose: The aim of this study was to investigate the accessory root canal morphology of maxillary first molars in a Black South African subpopulation.
Methods: Micro-computed tomography was used to investigate 101 maxillary first molars (from 50 male and 51 female teeth, right 53 teeth, left 48 teeth). The prevalence of chamber canals, and the number, type and location (root third) of accessory canals were recorded.
Article Synopsis
- Progress in genetic diagnosis and orphan drug legislation has led to new therapies for rare neurogenetic diseases (RNDs), but challenges remain in academia, regulation, and finances.
- The study aims to create a practical framework for developing patient registries that address these challenges and enhance outcomes in care, research, and drug development for RNDs.
- A comprehensive approach combining literature review, interviews with existing registries, and feedback from various stakeholders was used to ensure the framework meets diverse needs and emphasizes key principles like accessible, independent, and trustworthy data governance.