infection is associated with differences in transcriptionally active microbial communities.

infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost being billions of dollars. Gut microbiome dysbiosis is known to be important to CDI. To the best of our knowledge, metatranscriptomics (MT) has only been used to characterize gut microbiome composition and function in one prior study involving CDI patients.

Selection of ethanol tolerant strains of Candida albicans by repeated ethanol exposure results in strains with reduced susceptibility to fluconazole.

Candida albicans is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, C. albicans colonization has been shown to contribute to the progression and severity of alcoholic liver disease.

Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.

Background & Aims: Intestinal fungi have been implicated in the pathogenesis of ulcerative colitis (UC). However, it remains unclear if fungal composition is altered during active versus quiescent disease.

Methods: We analyzed clinical and metagenomic data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD), available via the IBD Plexus Program of the Crohn's & Colitis Foundation.

Selection of Ethanol Tolerant Strains of by Repeated Ethanol Exposure Results in Strains with Reduced Susceptibility to Fluconazole.

is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, colonization has been shown to contribute to the progression and severity of alcoholic liver disease. However, relatively little is known about how responds to changing environmental conditions in the GI tract of individuals with alcohol use disorder, namely repeated exposure to ethanol.