Instability of red cell shape associated with the absence of membrane glycophorin C.

Erythrocytes from 3 Gerbich-negative siblings readily converted to echinocytes when subjected to changing concentrations of sodium or lithium chloride. When erythrocyte membrane proteins were assayed by immunoblotting with human anti-Ge 1,2, normal membranes were found to contain a reactive component of an approximate molecular weight of 33,000 daltons which was absent from the Gerbich-negative individuals. PAS staining and mobility on SDS gels identified this component as glycophorin C.

Mild hemolytic disease of the newborn due to anti-Jk3: a serologic study of the family's Kidd antigens.

This report presents the first prospectively followed case of hemolytic disease of the newborn due to anti-Jk3 alone. A Samoan woman with known anti-Jk3 was closely monitored during her third pregnancy. Because of elevated delta OD values in the amniotic fluid and rising titer of serum antibody, labor was induced at 36 weeks gestation.