Mesenchymal Stem Cells-Derived Exosomes Combined With Bone Grafts Ameliorate Bone Regeneration in Mandibular Defects.

Although scaffold materials serve as effective bone substitutes for mandibular reconstruction, their high resorption and biodegradation rates decrease the success of the therapeutic effect. This study aims to explore the bone regenerative potential of bovine-derived osteoid matrix xenografts coupled with cell-free treatments. The study was conducted as a randomized in vivo experiment to repair critical-sized defects in rabbit mandibles.

The Optimal Effective Dose of Adipose-Derived Stem Cell Exosomes in Wound Healing.

Introduction: Although the effect of adipose-derived mesenchymal stem cell exosomes (ADSC-exos) on wound healing with different doses are shown in various studies, efficient and sufficient doses of ADSC-exos are still unknown. The study aimed to determine the optimal dose of ADSC-exos in wound healing.

Methods: The 45 Sprague-Dawley rats were randomly divided into five groups, with seven animals in each.

Evaluation of pituitary function and metabolic parameters in patients with traumatic maxillofacial fractures.

Purpose: This study was designed to assess the pituitary functions of patients with traumatic maxillofacial fractures and compare the results with healthy controls.

Methods: Thirty patients (mean age, 38.14 ± 14.

Comparison of the effectiveness of cyclosporine and tacrolimus in preventing acute rejection and their effects on kidney functions.

Objective: The aim of this study is to compare the effects of cyclosporine (CsA) and tacrolimus (TAC) on preventing acute rejection and analyze the side-effect profiles of both agents, particularly on kidney functions.

Patients And Methods: In our study, 71 patients who underwent heart transplantation were included. For maintenance immunosuppression, 28 of these patients were treated with mycophenolate mofetil (MMF), steroid, and steroid CsA, and 43 of them were treated with MMF steroid and TAC.

Thrombolytic treatment of right atrial thrombus in a patient with B cell acute lymphoblastic leukemia: a case report.

Right atrial thrombus is a severe complication of central venous catheterization (CVC). Concomitant pulmonary embolism may aggravate the clinical picture by causing or increasing shortness of breath and decreasing effort capacity, palpitations, and tricuspid valve regurgitation. A 32-year-old female patient with receiving chemotherapy was treated with alteplase thrombolysis because of the development of catheter-related right atrial thrombus and accompanying pulmonary embolism.