Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model.

Background: Machupo virus (MACV) is a New World mammarenavirus (hereafter referred to as "arenavirus") and the etiologic agent of Bolivian hemorrhagic fever (BHF). No vaccine or antiviral therapy exists for BHF, which causes up to 35% mortality in humans. New World arenaviruses evolve separately in different locations.

A split-GAL4 driver line resource for neuron types.

Techniques that enable precise manipulations of subsets of neurons in the fly central nervous system (CNS) have greatly facilitated our understanding of the neural basis of behavior. Split-GAL4 driver lines allow specific targeting of cell types in and other species. We describe here a collection of 3060 lines targeting a range of cell types in the adult CNS and 1373 lines characterized in third-instar larvae.

Mediating roles of weight stigma and physical activity avoidance in the associations between severity of gaming disorder and levels of physical activity among young adults.

Background And Aims: There are limited data regarding associations between gaming disorder and physical activity (PA). The present study investigated the direct association between these two variables and assessed the potentially mediating roles of PA avoidance and two types of weight stigma (i.e.

Follow-Up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non-Small Cell Lung Cancer.

Purpose: The prognostic value of molecular residual disease (MRD) in non-small cell lung cancer (NSCLC) is well-established, with treatment-guiding results anticipated. Here, we present updated analyses from our previous published cohort study of 261 NSCLC patients undergoing complete resection.

Experimental Design: 261 patients with stage I-III lung cancer who underwent radical surgery were enrolled.

Digital Mini-LED Lighting Using Organic Thin-Film Transistors Reaching over 100,000 Nits of Luminance.

This paper demonstrates the use of organic thin-film transistors (OTFTs) to drive active digital mini light-emitting diode (mini-LED) backlights, aiming to achieve exceptional display performance. Our findings reveal that OTFTs can effectively power mini-LED backlights, reaching brightness levels exceeding 100,000 nits. This approach not only enhances image quality but also improves energy efficiency.