Publications by authors named "C A Holden"
Article Synopsis
- Panic disorder is expensive to manage, and though there are effective treatments, getting a diagnosis often limits access to them.
- Current diagnostic methods classify panic disorder strictly as either having it or not, which contradicts research suggesting a more nuanced, dimensional approach.
- Recent studies using taxometric analyses on data from 663 participants indicate strong support for a dimensional model of panic disorder, which could improve how we measure, diagnose, and treat the condition.
Aims: Accruing evidence illustrates an emerging paradigm of dynamic vascular smooth muscle cell (SMC) transdifferentiation during atherosclerosis progression. However, the molecular regulators that govern SMC phenotype diversification remain poorly defined. This study aims to elucidate the functional role and underlying mechanisms of cellular communication network factor 2 (CCN2), a matricellular protein, in regulating SMC plasticity in the context of atherosclerosis.
View Article and Find Full Text PDFObjective: Shared decision making is important when decisions are preference sensitive, as in incurable cancer. A prerequisite for shared decision making is health literacy, which is essential to facilitate good understanding of an individual's current situation, the decision to be made, and the options available to them. This study sought to learn about the challenges for shared decision making faced by patients with incurable cancer and health literacy difficulties.
View Article and Find Full Text PDFWe introduce a novel LoRa-based multi-hop communication architecture as an alternative to the public internet for earthquake early warning (EEW). We examine its effectiveness in generating a meaningful warning window for the New Zealand-based decentralised EEW sensor network implemented by the CRISiSLab operating with the adapted Propagation of Local Undamped Motion (PLUM)-based earthquake detection and node-level data processing. LoRa, popular for low-power, long-range applications, has the disadvantage of long transmission time for time-critical tasks like EEW.
View Article and Find Full Text PDFArticle Synopsis
- Acrylate polymers and cross-polymers (ACPs) are common in cosmetics, and a study by the BSCA and CTPA aimed to assess their potential for causing allergic reactions.
- The study involved patch testing over 1300 patients for reactions to three specific ACPs, finding very few cases of irritant or doubtful reactions, with no confirmed allergies to one of the compounds tested.
- The overall conclusion is that sensitization to these ACPs at the concentrations tested is rare, suggesting minimal risk of dermatitis in patients already sensitive to (meth)acrylates.