Publications by authors named "C A Heinen"

Background: The challenging transition to parenthood affects both mothers and fathers; yet, the strain intensifies with a premature birth in the neonatal intensive care unit (NICU), underscoring the importance of acknowledging and addressing potential differences in parental roles.

Purpose: This paper aimed to investigate how parental role conflicts among mothers and fathers of preterm-born infants hospitalized in German NICUs manifest and investigated potential parental resources.

Methods: Twenty-four participants, 17 mothers, and seven fathers of very low birth-weight infants were interviewed.

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Objectives: Congenital adrenal hyperplasia (CAH) is a rare, inherited disorder of adrenal steroid synthesis. In many countries it is part of the neonatal screening program enabling early diagnosis and treatment. In case of an abnormal neonatal screening result or when other differences of sexual development (DSD) are suspected, measurement of serum steroid hormones using liquid chromatography coupled to mass spectrometry (LC-MS/MS) is needed for further diagnosis.

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Article Synopsis
  • Fragility fractures of the pelvis (FFP) primarily affect patients with osteoporosis and are often difficult to diagnose using conventional CT, with MRI being the gold standard for accurate detection.* -
  • This study compares the diagnostic accuracy of Spectral CT to MRI by examining patients with suspected FFP, finding that while Spectral CT has slightly lower sensitivity than MRI, it can still identify additional fractures effectively.* -
  • The results show that Spectral CT maintained good specificity and inter-rater reliability, suggesting it could be a valuable tool in uncertain cases of FFP diagnosis.*
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Evidence from in vitro studies and observational human disease data suggest the complement system plays a significant role in SARS-CoV-2 pathogenesis, although how complement dysregulation develops in patients with severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y) and a mouse model of severe COVID-19, we identify significant serologic and pulmonary complement activation following infection. We observed C3 activation in airway and alveolar epithelia, and in pulmonary vascular endothelia.

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