Publications by authors named "C A Hedin"
Article Synopsis
- The study aimed to find protein signatures in blood that could help identify individuals at high risk for inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis.
- Researchers analyzed blood samples from a large population, utilizing machine-learning methods to identify and validate these protein signatures across multiple cohorts.
- A specific combination of 29 proteins was effective in differentiating preclinical CD cases from controls, achieving a high accuracy, while the prediction for ulcerative colitis was less robust but still significant.
Objectives: The optimal nutritional management during a severe flare of inflammatory bowel disease is uncertain. The goal of this study was to describe variations in nutritional practices between different countries, professions and types of hospitals, as well as between ulcerative colitis (UC) and Crohn's disease (CD).
Methods: In this cross-sectional study, a novel questionnaire was distributed in the ECCO Congress 2022 and via ECCO country representatives.
Background: Recent genetic and transcriptomic data highlight the need for improved molecular characterisation of inflammatory bowel disease (IBD). Proteomics may advance the delineation of IBD phenotypes since it accounts for post-transcriptional modifications.
Aim: We aimed to assess the IBD spectrum based on inflammatory serum proteins and identify discriminative patterns of underlying biological subtypes across multiple European cohorts.
Background And Study Aims: Lynch syndrome (LS) is a hereditary autosomal dominant condition, with an increased lifetime risk of developing malignancies including colorectal cancer (CRC). Current guidelines differ in recommended colonoscopy-surveillance intervals from 1 to 2 years. Although colonoscopy is considered a safe procedure, there are risks of severe adverse events (SAEs), such as perforation and bleeding, as well as adverse events (AEs), such as abdominal discomfort and post-colonoscopy gastrointestinal infections.
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