Publications by authors named "C A Harlow"
Article Synopsis
- The study aimed to assess how bariatric surgery affects the way the body processes orally taken medications and supplements.
- It analyzed data from 58 studies involving 1985 participants, focusing on specific drugs and supplements, and found that while some showed changes in pharmacokinetic (PK) parameters post-surgery, others did not.
- The conclusion highlighted significant variability in study results, emphasizing the need for more research to establish effective practices for medication management after bariatric surgery.
Context: One of the major prognostic indices in neuroendocrine tumors (NETs) is Ki67 proliferation index.
Objective: To identify optimal grading Ki67 cutoffs to delineate differences in prognosis of patients with small intestinal NETs (SI-NETs).
Methods: Multicenter retrospective cohort analysis of 551 SI-NET patients diagnosed from 1993 through 2021 at 5 European referral centers with a mean (±SD) follow-up time of 51.
Article Synopsis
- HIF-PHIs are being developed to treat anemia in CKD, but it's crucial to ensure they are safe for the heart.
- Genetic variants can potentially predict the risk of adverse cardiovascular effects from these treatments.
- A specific genetic variant related to EPO levels was identified and tested, showing no increased risk of coronary artery disease, heart attack, or stroke with higher EPO levels, indicating a safer profile for these therapies.
Article Synopsis
- Prolyl hydroxylase (PHD) inhibitors are being tested to treat anemia in chronic kidney disease, but studies on their long-term safety regarding cardiovascular disease (CVD) risks have shown mixed results.
- Using Mendelian randomization, researchers analyzed data from over 60,000 coronary artery disease cases and found no significant increase in CVD risk related to long-term rises in hemoglobin levels due to PHD inhibition.
- A phenome-wide association study indicated some associations with blood-related traits and kidney/liver biomarkers, but these were not clinically significant, suggesting PHD inhibitor-related hemoglobin increases likely do not elevate CVD risk.
Introduction: The Covid-19 pandemic brought significant disruption to post-graduate medical education. Lecture-based training days were rapidly converted to webinars. This study aims to assess the perceptions of digital training in internal medical trainees.
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