Publications by authors named "C A Guest"
J Thromb Haemost
January 2025
Article Synopsis
- * The treatment strategy combined high-dose intravenous immunoglobulin (IVIG) and high concentrations of heparin to lessen the risk of platelet activation during surgery.
- * Results showed that preoperative IVIG significantly reduced platelet activation, allowing the safe use of standard heparin during the surgery without causing thrombosis.
Dis Model Mech
November 2024
Article Synopsis
- Chemotherapy-induced neuropathic pain (CINP) is a significant issue for pediatric cancer survivors, and current pain treatments are not effective due to limited understanding of CINP mechanisms.
- This study explores how cisplatin leads to neuroinflammation and increased pain sensitivity through nerve growth factor (NGF) interactions, particularly focusing on macrophage activity in the dorsal root ganglia (DRG).
- The research findings suggest that targeting the NGF-TrkA signaling pathway in macrophages may offer new pain relief strategies for adults who survived childhood cancer.
Article Synopsis
- Dogs can differentiate between human stress and relaxation scents, but the impact on their cognitive behavior was previously unexplored.
- A cognitive bias task showed that when exposed to human stress odors, dogs were less likely to approach food bowls placed in ambiguous locations, indicating they may exhibit risk-reduction behaviors.
- The study suggests that olfactory cues of human stress can influence dogs' learning and cognition, highlighting potential implications for dog welfare and their working abilities.
Open Forum Infect Dis
July 2022
Article Synopsis
- The ongoing COVID-19 pandemic has highlighted the need for effective and rapid screening methods as traditional diagnostics are costly and time-consuming, while vaccinations remain unevenly accessible globally.
- A study was conducted using medical detection dogs trained to identify SARS-CoV-2-positive sweat samples from individuals, showing high accuracy with 98% sensitivity and 92% specificity in detecting the virus.
- The results suggest that using canine olfaction could serve as a reliable, non-invasive screening tool for diagnosing COVID-19, even among asymptomatic patients.
