Ankle Angle Prediction Using a Footwear Pressure Sensor and a Machine Learning Technique.

Ankle injuries may adversely increase the risk of injury to the joints of the lower extremity and can lead to various impairments in workplaces. The purpose of this study was to predict the ankle angles by developing a footwear pressure sensor and utilizing a machine learning technique. The footwear sensor was composed of six FSRs (force sensing resistors), a microcontroller and a Bluetooth LE chipset in a flexible substrate.

Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.

A major challenge in platinum-based cancer therapy is the clinical management of chemoresistant tumors, which have a largely unknown pathogenesis at the level of epigenetic regulation. We evaluated the potential of using global loss of 5-hydroxymethylcytosine (5-hmC) levels as a novel diagnostic and prognostic epigenetic marker to better assess platinum-based chemotherapy response and clinical outcome in high-grade serous tumors (HGSOC), the most common and deadliest subtype of ovarian cancer. Furthermore, we identified a targetable pathway to reverse these epigenetic changes, both genetically and pharmacologically.

Riding a bus while seated in a wheelchair: A pilot study of attitudes and behavior regarding safety practices.

A total of 283 wheelchair-seated bus riders responded to a 35-item Web-based survey investigating their experiences on public, fixed-route buses. The survey addressed the use of wheelchair tiedowns and occupant restraint systems (WTORS), the attitudes and behaviors of wheelchair users toward the use of this equipment, and the transit experience. Results indicate that consistent use of four-point tiedown and occupant restraint systems is fairly low.