Eco-geomorphic modelling response of tidal marshes to sea level rise and changes in suspended sediment supply.

Tidal marshes are coastal systems that provide valuable ecosystem services, highlighting coastal protection and carbon burial. For centuries, these dynamic ecosystems have kept pace with sea level rise through organic and mineral matter accumulation. In the current situation of accelerated sea-level rise and changes in suspended sediment concentrations, the evolution of these systems has gained special attention across scientific fields.

Targeting human plasma cells using regulated BCMA CAR T cells eliminates circulating antibodies in humanized mice.

Pathogenic long-lived plasma cells (LLPCs) secrete autoreactive antibodies, exacerbating autoimmune diseases and complicating solid organ transplantation. Targeted elimination of the autoreactive B cell pool represents a promising therapeutic strategy, yet current treatment modalities fall short in depleting mature PCs. Here, we demonstrate that chimeric antigen receptor (CAR) T cells, targeting B cell maturation antigen (BCMA) utilizing a split-receptor design, offer a controlled and effective therapeutic strategy against LLPCs.

Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.

We previously showed that inhibition of glycolysis in cutaneous squamous cell carcinoma (SCC)-initiating cells had no effect on tumorigenesis, despite the perceived requirement of the Warburg effect, which was thought to drive carcinogenesis. Instead, these SCCs were metabolically flexible and sustained growth through glutaminolysis, another metabolic process frequently implicated to fuel tumorigenesis in various cancers. Here, we focused on glutaminolysis and genetically blocked this process through glutaminase (GLS) deletion in SCC cells of origin.